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Chronic release of proinflammatory cytokines of innate immunity, increased Treg cell activity, aerobic glycolysis of infected cells, and activation of neutrophils by ANCA lead to excessive ROS production, and this could explain the increased oxidative and nitrosative stress, depletion of antioxidant substances, increased aerobic glycolysis in circulating cells, and increased damage to fatty acids, DNA, and proteins that occur in patients with ME/CFS [296–298, 360]
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Because the body recognizes candida glycoconjugates as a foreign invader to be eliminated, there is medical research into developing glycoconjugate-based medications/vaccines to help the body recognize and fight off fungal infections (see: Fungal Glycans & Immune Recognition)
