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Pharmacokinetics of probe drugs and kratom alkaloids Relative to baseline, the kratom tea increased midazolam geometric mean AUC 0–12 , AUC inf , and C max by 40–50% and had no effect on t 1/2 and median t max (Figure 2, Table 1)

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Different studies have noted this association across a range of dietary exposures including coffee, black tea, green tea and total caffeine intake