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On the other hand, over the past 15 to 20 years, evidence has emerged that GSH plays a crucial role in cell proliferation, promoting the idea that GSH depletion may enhance the efficacy of cancer treatments [8,10,20], so the role of GSH must be analyzed in light of the pathophysiology and desired outcome

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The association between ER stress and mitochondrial dysfunction in individuals with ME/CFS was intriguing given the link between this disorder and viral infections which are well-known to disrupt ER homeostasis (34, 36, 86)