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Individuals who might theoretically be candidates for both treatments could include: Men with obesity and hypogonadism , where weight loss is a clinical priority alongside hormone replacement Transgender men on testosterone therapy who also have obesity-related metabolic conditions Individuals enrolled in clinical trials investigating retatrutide's effects on metabolic syndrome, where testosterone use is a pre-existing condition It is important to note that combining an unlicensed investigational drug with a licensed hormone therapy requires careful oversight

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Moreover, the expected weight reduction in those with extreme obesity may be insufficient to meet all desired health outcomes and goals