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However, it is now known that cereblon expression has an impact on therapeutic response, with low expression resulting in a null or weak response to IMiDs 197

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However, more important is the practical evidence from a considerable number of the studies, particularly in gastrointestinal research, that intragastric administration or per os administration in drinking water, is equally effective as injections of the supplement administered to rodents, which has been performed in the majority of studies on BPC 157