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Specifically, it highlighted a regulatory consistent sub-network change with increased abundances in three xanthine metabolites (xanthine, hypoxanthine, and inosine) and decreased gene expression for the associated enzyme hypoxanthine phosphoribosyltransferase 1 ( HPRT1 ), which catalyzes the conversion of hypoxanthine and phosphoribose diphosphate into inosine monophosphate (IMP) and pyrophosphate (see Fig

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Impressively, when ανβ3 integrin was combined with 808-nm NIR laser irradiation, the cytotoxic impact on ανβ3 integrin-overexpressing tumor cells intensified, reducing HeLa cell viability to 45% (Fig