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also confirmed that LT 4 treatment did not reduce miscarriage rates or increase live birth rates in women undergoing in vitro fertilization embryo transfer (IVF-ET) with intact thyroid function and positive TPOAb (Wang et al., 2017)

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In conclusion, our study revealed a previously unidentified function of the ER stress sensor protein IRE1α in determining cellular sensitivity to ferroptosis through regulating GSH availability, a finding that may lead to the development of treatment strategies for ferroptosis-associated normal tissue damage and improvement in the efficacy of existing cancer therapies