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Search strategy The following keywords were used for searches of publications published from 2014 to 2024 in Chinese and English databases, including China National Knowledge Infrastructure (CNKI), PubMed, and Web of Science (SCIE): “sciatic nerve injury,” “animal models,” “Chronic constriction injury,” “Partial sciatic nerve ligation,” “Spared nerve injury,” “Sciatic nerve crush injury,” “Sciatic nerve transection,” “treatment of sciatic nerve,” “Neurotrophic agents,” “Antioxidant,” “Anti-inflammatory,” “Tissue engineering” and “stem cell therapy.” In addition to focusing on the relevant articles between 2014 and 2024, we also traced many of the original literature on sciatic nerve injury modeling methods to ensure a comprehensive understanding of sciatic nerve injury modeling (Figure 2)