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General information, not advice about these materials In clinical practice, an ordinary local reaction to a subcutaneous injection is distinguished from two situations that are assessed by a doctor: signs of infection (redness that spreads, warmth, fever, discharge, or a site that is worse after 48 hours rather than better) and signs of a systemic allergic response (hives beyond the site, swelling of the lips, face or throat, or difficulty breathing, which is an emergency and a reason to call the local emergency number, 112 across the EU)
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2010;66(Pt 1):12–21