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Accordingly, tumor cells lacking functional p53 were found more resistant to cisplatin than cells that contained functional p53 and the resistant cell lines were sensitized to cisplatin upon reconstitution with wild-type p53 (9)

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Functionally, deletion of HP1β has been linked to increased expression of γ-H2AX, defects in DNA replication, and associated DNA damage that affects spermatogenesis [107]