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The distinctive tumor microenvironment (TME), unveiling a more acidic condition (low pH), hypoxia, overexpression of glutathione (GSH), elevation of certain enzymes as a consequence of their uncontrolled proliferation and rapid metabolism, 4 has become a topic of interest to modify the anticancer mechanisms of drugs so that the drugs can compel the cancer cells to undergo programmed cell death (apoptosis)

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10.1016/j.jep.2024.118425 [DOI] [PubMed] [Google Scholar] Hu S., Li A., Huang T., Lai J., Li J., Sublette M