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While the cyclophosphamide administration in moderate doses of 100 mg/kg improved the survival of treated mice and lead to a reduction in the B cell compartment, a dose escalation amplified the effect even further on the B cell level irrespective of the CAR-T cell dose administered
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However, there remains significant scope for exploration and several issues that require attention in the research on ferroptosis and bone metabolism: currently, research on the regulatory role of ferroptosis in osteoporosis predominantly focuses on two mechanisms: iron overload and lipid peroxidation
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