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ghk-cu tolerance or desensitization or loss of effectiveness long-term use downregulation ghk cu antibody formation The Effect the Frontiers | Exploring the beneficial –

Experimental Methods Transgenic mice and cuprizone administration SphK2 knockout mice (SphK2 −/− ) (RRID: IMSR_JAX:019140) were obtained under MTA with Prof Richard Proia, NIDDK, Bethesda, USA and genotyped as described (Mizugishi et al., 2005)

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Li L, Shu F, Wang XQ, Wang F, Cai L, Zhao X