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TNF inhibitors are for tamariki who have: severe Crohn's disease, or symptoms that don't improve when they take other medicines, or a complication of Crohn’s disease that involves a fistula (an abnormal connection between the intestine and the skin or between two parts of the intestine) Examples of TNF inhibitors are: infliximab (given as an infusion via an IV line) adalimumab (given as an injection under the skin) Ustekinumab Ustekinumab is a medicine that works by blocking another inflammatory substance in your body