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The one human ulcerative-colitis dataset that regulators have actually reviewed, a rectal-enema pilot, was judged by the FDA to be too limited and poorly reported to establish effectiveness, and notably the drug was not detectable in plasma by that route, with human studies and clinical trials in GI disease still sparse and poorly reported

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In this phase, the liver attaches a glutathione molecule to a toxin to make it water-soluble so it can be flushed out of the system