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Common adverse reactions reported in over 5% of patients treated with semaglutide include: Nausea Vomiting Diarrhea Abdominal pain Constipation Call your healthcare provider immediately if you experience any signs of an allergic reaction, including wheezing, chest tightness, fever, itching, bad cough, blue skin color, severe behavioral problems, chest pain or pressure, fast heartbeat, severe dizziness, passing out, nervousness and excitability, severe headache, or fits or swelling of the face, lips, tongue, or throat, How to reduce semaglutide side effects Your provider may start your weekly injections at a low dose and gradually increase to the prescribed dosage to minimize potential side effects