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Key Takeaways SLUPP-332 activates estrogen-related receptors (ERRα/γ), driving mitochondrial biogenesis and fat oxidation in preclinical research MOTS-C is a mitochondria-derived peptide that activates AMPK and supports metabolic flexibility under stress 5-Amino-1MQ inhibits NNMT (nicotinamide N-methyltransferase), raising intracellular NAD+ precursors and supporting energy metabolism The three compounds target different but complementary pathways , which is why researchers study them as a stack No human clinical trials on this specific combination exist as of 2026