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The β-isoform of interleukin-1, acting through canonical NF-κB signal relay, potentiates the inflammatory cascade by inducing pyrogenic responses, enhancing the transcriptional upregulation of endothelial counter-receptors for immune cell arrest, and facilitating the recruitment and translocation of circulating leukocyte subsets [171,172,173,174]

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Therefore, competitive athletes should check current anti-doping rules and speak with their relevant sports medicine or anti-doping organization before using BPC-157