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​ Within a day Fatigue lessens (although this can sometimes take some weeks) Become more sociable Mood improvements Better quality of sleep Within a week Brain fog lifts Numbness and pins and needles start to remit Within 2 weeks Strength may return to muscles and joints Within a month Pains in hands and feet remit Strength and grip improve Cyclical hormones such as fertility cycles normalise Thyroid and cortisol hormones normalise ​ ​** These results cannot be guaranteed, and can depend on your other lifestyle factors such as diet, sleep health, alcohol / drug intake etc

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[2] Oral B12 supplementation generally takes longer to produce effects , with patients often noticing energy improvements within two to four weeks