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In an MCAO/R model using ICR mice, prophylactic administration of PACs via gavage at a minimum dose of 25 mg/kg daily for 7 days enhanced neurological function, reduced infarct volume, and activated the Nrf2/HO-1 signaling pathway

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Alternatively, the failure to replicate uniformly the benefits seen in preclinical studies in clinical studies may lie in the nature of neuropsychiatric diagnoses