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Description AOD-9604 (Fragment 176-191) is a synthetic peptide consisting of the C-terminal 16-amino-acid segment of human growth hormone (hGH), corresponding to residues 176 through 191
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Similarly, environmental enrichment, which provides enhanced sensory, cognitive, and motor stimulation, can elevate BDNF levels and, when combined with therapies that bolster TrkB expression (as demonstrated with the peptide P42 in an HD mouse model), synergistically delays disease progression and improves motor and cognitive outcomes (Couly et al., 2021)