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Retinal proteins modified by 4-hydroxynonenal: identification of molecular targets

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Direct immunofluorescence studies reveal deposition of C3, C5b-9, and IgG in a granular pattern at the dermal–epidermal junction and in and around vessel walls in affected individuals.44,103 These changes are most apparent in sun-exposed areas of patients with active disease and high urinary porphyrin excretion, and they decrease substantially in patients after appropriate treatment

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