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2.2.5.1 The engineering continuum: from stochastic entrapment to information-driven programming Virus-like particle interior loading strategies can be conceptualized along a continuum defined by the degree of molecular recognition between the capsid architecture and the intended cargo: Physical and charge-mediated strategies (the bulk-driven regime): these represent the most accessible domains of the continuum, relying on thermodynamic randomness or coulombic affinity

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