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The brain’s restricted antioxidant capacity, high energy demand, high levels of transition metals, such as iron and copper, and a high concentration of polyunsaturated fatty acids which can be subjected to lipid peroxidation [103,104,105] make the nervous system particularly vulnerable to oxidative stress [106]

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KPV lacks the His-Phe-Arg-Trp message core that melanocortin receptors recognise, so research has instead focused on PepT1-mediated cellular uptake followed by intracellular signalling, particularly in mucosal and gut-barrier models where intact α-MSH signalling is preserved without the pigmentation effects of the parent peptide