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GLP-1 RAs improve many CV risk factors (obesity, hypertension, dyslipidemia, inflammation, visceral/hepatic fat, hyperglycemia), but the magnitude of improvement in these CV risk factors was modest in the LEADER and SUSTAIN-6 studies and unlikely to explain the reduction in primary outcome (3-point MACE) when reviewed individually

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Acetate was the second most abundant metabolite produced, reaching a maximum of 50 mmol gDCW -1 in cultures without ethanol