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Abbreviations : GW4064 the FXR agonist, ALD Alcoholic liver disease, C/EBPα CCAAT-enhancer-binding protein α, FXR Farnesoid X receptor, EWCDs Fluorescent egg white-based carbon dots, NAFLD Nonalcoholic fatty liver disease, NF-Κb Nuclear factor kappaB, YAP Yes-associated protein, NCOA4 Nuclear receptor coactivator 4, PA/OA Palmitic acid (PA)/oleic acid (OA), Mito-TEMPO Mitochondrial ROS scavenger, LPT1 Ferroptosis inhibitor liproxstatin-1, DFP Iron chelator deferiprone, SFN Sulforaphane, CoA Coenzyme A (CoA), Nrf2 Nuclear factor erythroid 2–related factor 2, TfR1 Membrane transferrin receptor 1, Au8-pXs ROS detoxifying gold quantum clusters, FRDA Friedreich ataxia, SNH6 6-methoxy-2-salicylaldehyde nicotinoyl hydrazone, NAD Nicotinamide Adenine Dinucleotide, DFX Deferoxamine, T2DM Type 2 diabetes mellitus, OA Osteoarthritis, HO-1 Heme oxygenase-1, DFO Deferiprone, Fer-1 Ferrostatin-1, HD Huntington's disease, PVL Periventricular leukomalacia, DoIC Doxorubicin DOX-induced cardiotoxicity, GSH Glutathione, DN Diabetic nephropathy, MDA Malondialdehyde, DFAs new deferric amine compounds, FXN Frataxin, BMP6 Bone morphogenetic protein 6, ACVR1 Activin A receptor type I, SMAD Suppressor of Mother against Decapentaplegic, IL-6 Interleukin-6, STAT3 Signal Transducer And Activator Of Transcription 3, MF Myelofibrosis, HUCMSCs Human umbilical cord mesenchymal stem cells, SLC7A11 Glutamate-cystine-exchanger Xct, DMED Diabetic mellitus erectile dysfunction, Pkd1 Gene encoding polycystin-1, ADPKD Autosomal dominant polycystic kidney disease, 4HNE 4-hydroxynonenal, AKT Akermanite, S6 Phosphorylated ribosomal S6 protein, CPX Ciclopirox, CPX-O Ciclopirox’s olamine salt, PKD Polycystic kidney disease, Rosi ACSL4 inhibitor rosiglitazone, BCA Biochanin, IOKOA Iron overload-induced KOA, PAESe Phenylaminoethyl selenides, PPAR-γ Peroxisome proliferator activated receptor gamma Conclusion and perspective Ferroptosis, a form of regulated cell death characterized by iron-dependent accumulation of lipid hydroperoxides, has emerged as a significant area of study in cell biology and disease research
