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In addition, a higher relative abundance of Escherichia coli was noted in the control group, which indicated diet supplemented with mixed organic acid promoted intestine health by reducing harmful pathogenic bacteria, which were identified by numerous broilers studies ( Conclusions In summary, our findings demonstrated the beneficial impacts of the broiler dietary supplementation with mixed organic acid enhanced the immune characteries and antioxidative function in serum and small intestine, promoted the digestive enzyme activity of the pancreas, improved the expression of tight junction proteins, and modulated the cecum bacterial community, which achieves a better healthy growth for broilers