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Systemic, intraperitoneal (100 μg/kg) or oral (10 mg/kg) delivery of celastrol can dramatically decrease body weight (up to 45%) in mice with DIO but not in leptin-deficient ob/ob mice, db/db mice or lean control mice 107

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doi: 10.1016/j.fertnstert.2010.06.038

It helps convert fat into energy