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We also acknowledge CFREF BrainsCAN funding that we received providing a reduced hourly rate for the MRI scans
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8,9,25–27,34–39,68,69 The gliadin p31-43 peptide induces cellular stress, activates proliferative mechanisms of cryptic epithelial cells, drives enterocyte stress, induces a Ca 2+ surge (thus activating the CD autoantigen tTG), triggers a local pro-inflammatory storm, activates the NFκB signaling pathway, inhibits CFTR (cystic fibrosis transmembrane conductance regulator, an ion channel protein), alters vesicular trafficking, activates the inflammasome platform, and reduces autophagy