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Also, a decrease in the levels of CoQ biosynthetic proteins has been related to secondary CoQ deficiency in various mouse models of mitochondrial diseases [7], as well as in muscle and adipose tissue of patients and a mouse model with insulin resistance [8]

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Ranking alpha lipoic acid and gamma linolenic acid in terms of efficacy and safety in the management of adults with diabetic peripheral neuropathy: A systematic review and network meta-analysis