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AICAR, the AMPK-activating exercise-mimetic candidate, increased running endurance in sedentary mice by 44% in the well-known 2008 Cell study [14] — and then, in a randomised Phase 3 cardiac-surgery trial stopped for futility after 3,080 of a projected 7,500 patients had been randomised, produced a primary-outcome rate of 5.1% versus 5.0% on placebo [15]

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however, the findings are still limited to lab research

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