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Gene editing (Cas9 mRNA/NLRP3-sgRNA) for psoriasis therapy 6-8 weeks old female Balb/c mice were randomly divided into four groups, including normal health group, imiquimod modeling group, NLRP3-targeting Cas9/sgRNA loaded cLNPs group, and NLRP3-targeting Cas9/sgRNA loaded AO 12 LNPs group