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In the healing of the perforated stomach in the first 15 min, there was initially elevated NOS-2 and decreased VEGFa, then elevated NOS-2 and decreased VEGFa, then elevated COX-2, NOS-1, NOS-2, NOS-3, and then elevated COX-2, NOS-2, and decreased NOS-3 gene expression [144]

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In laboratory settings, GHK-Cu has been reported to stimulate collagen synthesis by up to 70% in fibroblast cultures and to modulate the expression of more than 60 genes involved in tissue remodeling, antioxidant defense, and inflammation control