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In the SUSTAIN 8 study, patients with T2DM exhibited a lean mass decrease of 2.3 kg alongside a total weight loss of 5.3 kg, resulting in 43.4% of weight loss attributable to lean mass, while the ratio of lean mass to total mass increased by 1.2% from the baseline [111]

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The major sensors that are involved in the activation of mTOR ubiquitylation are depletion of Arg, Gln, and Leu