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In addition, ursodeoxycholic acid produced by Lactobacillus acidophilus inhibits proinflammatory macrophage polarization by upregulating RapGAP (Deng et al., 2024)

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Remarkably, cell lines with missense TP53 mutations, which typically accumulate mut-p53 protein, are most sensitive to knockdown of SLC7A11 than any other antioxidative stress gene (Fig