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Key conclusions from ongoing pharmacovigilance: Confirmed safety signals (consistent with clinical trial findings): GI adverse events (nausea, vomiting, diarrhea, constipation) - most common side effects, consistent with mechanism Gallbladder events (cholelithiasis, cholecystitis) - increased with weight loss, consistent with known physiology Injection site reactions - uncommon, typically mild Acute pancreatitis - rare, background-rate consistent, causal relationship uncertain Under investigation (signals emerging from post-marketing data): Suicidal ideation and psychiatric effects - EMA investigation ongoing

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