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The novelty of this review lies in its integrative approach, moving beyond a mere description of disparate pathways to synthesize a coherent framework that connects key metabolic nodes—such as the mammalian target of rapamycin (mTOR)-hypoxia-inducible factor 1-alpha (HIF-1α)-glycolysis axis, AMP-activated protein kinase (AMPK)-FAO signaling—into a dynamic immunometabolic network ( Figure 1 )

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However, a 2003 systematic review highlighted differences in methodologies between early and later studies that make it difficult to compare results (104)