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The landscape of small-molecule prodrugs | Nature Reviews Drug Discovery
The latter activity could positively feedback into NF-kB mediated transcription of proinflammatory cytokines.[29,133] Peptostreptococcus , Eubacterium , Selenomonas , Centipede , Bacteriodes , and Fusobacterium also metabolized cysteine to produce volatile sulfur compounds.[134] Moreover, Chapple[5,34] advocated that degradation of cysteine by oral microorganisms may also prevent the inhibition of NF-kB mediated production of pro-inflammatory cytokines in the periodontal environment, and hence cytokine related tissue destruction
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Therefore, while this strategy is mechanistically attractive, it still requires more safety and population stratification evidence before forming a clear clinical pathway