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Importantly, since both glutamate export and cysteine import via system XcT are tightly linked to ferroptosis regulation, changes in glutamate or cysteine availability resulting from altered 5-OP metabolism could significantly impact cellular susceptibility to oxidative stress (Figure 3E)

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Storage Stability and Reconstitution Specifics The structural modifications that give IGF-1 LR3 its IGFBP resistance also affect its storage and handling properties in research settings