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A 60×60×60 Å grid box was also set for covering the entire surface of the receptor with a default grid point spacing of 0.375 Å

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407 , 408 In the AD model, oral pathogens (such as Porphyromonas gingivalis ) drive systemic inflammation by altering the structure of the intestinal microbiota, inducing intestinal barrier dysfunction and endotoxin translocation 409 and simultaneously promoting the activation of peripheral immune cells