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Regarding histone methylation, SAMe depletion has been identified to favor mono-methylation of H3K9 over di-and tri-methylation which preserves heterochromatin stability [62], but also changes in H3K4 trimethylation patterns have been identified in response to modulation of SAMe levels [64]

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Stress-induced symptom exacerbation: stress increases voiding frequency, somatic sensitivity, and urinary bladder NGF and BDNF expression in mice with subthreshold cyclophosphamide (CYP)