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The distinctive tumor microenvironment (TME), unveiling a more acidic condition (low pH), hypoxia, overexpression of glutathione (GSH), elevation of certain enzymes as a consequence of their uncontrolled proliferation and rapid metabolism, 4 has become a topic of interest to modify the anticancer mechanisms of drugs so that the drugs can compel the cancer cells to undergo programmed cell death (apoptosis)

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“Chapter 4 - naphthaquinones††The protoaphins are discussed in Chapter 7,” in Naturally occurring quinones