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For HIV/AIDS, FDA approves next best thing to a vaccine | STAT

The metabolic reprogramming includes a 2.1-fold increase in glycolytic activity (Warburg effect) accompanied by 4.3-fold elevation in malondialdehyde (MDA) levels, indicating oxidative stress-mediated metabolic reorganization (55)

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These reductions represented estimated treatment differences ranging from 3.0% to 7.8% weight loss versus placebo, all of which were statistically significant