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Inherited defects in tryptophan transport and metabolism result in severe clinical disorders attributed to NAD + depletion (see Niacin-responsive genetic disorders)

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In plants, Cu/Zn-SOD is predominantly in chloroplasts, cytoplasm, and peroxidase, while Mn-SOD and Fe-SOD are predominantly in mitochondria and chloroplasts, respectively (Du et al., 2001)